Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data
Identifieur interne : 002C71 ( Main/Exploration ); précédent : 002C70; suivant : 002C72Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data
Auteurs : Lynnette Fernandez-Cuesta [Allemagne, France] ; Ruping Sun [Allemagne, États-Unis] ; Roopika Menon [Allemagne] ; Julie George [Allemagne] ; Susanne Lorenz [Norvège] ; Leonardo A. Meza-Zepeda [Norvège] ; Martin Peifer [Allemagne] ; Dennis Plenker [Allemagne] ; Johannes M. Heuckmann [Allemagne] ; Frauke Leenders [Allemagne] ; Thomas Zander [Allemagne] ; Ilona Dahmen [Allemagne] ; Mirjam Koker [Allemagne] ; Jakob Schöttle [Allemagne] ; Roland T. Ullrich [Allemagne] ; Janine Altmüller [Allemagne] ; Christian Becker [Allemagne] ; Peter Nürnberg [Allemagne] ; Henrik Seidel [Allemagne] ; Diana Böhm [Allemagne] ; Friederike Göke [Allemagne] ; Sascha Ansén [Allemagne] ; Prudence A. Russell ; Gavin M. Wright ; Zoe Wainer ; Benjamin Solomon ; Iver Petersen [Allemagne] ; Joachim H. Clement [Allemagne] ; Jörg S Nger [Allemagne] ; Odd-Terje Brustugun [Norvège] ; Slaug Helland [Norvège] ; Steinar Solberg [Norvège] ; Marius Lund-Iversen [Norvège] ; Reinhard Buettner [Allemagne] ; Jürgen Wolf [Allemagne] ; Elisabeth Brambilla [France] ; Martin Vingron [Allemagne] ; Sven Perner [Allemagne] ; Stefan A. Haas [Allemagne] ; Roman K. Thomas [Allemagne]Source :
- Genome Biology [ 1465-6906 ] ; 2015.
Abstract
Genomic translocation events frequently underlie cancer development through generation of gene fusions with oncogenic properties. Identification of such fusion transcripts by transcriptome sequencing might help to discover new potential therapeutic targets. We developed TRUP (Tumor-specimen suited RNA-seq Unified Pipeline) (
The online version of this article (doi:10.1186/s13059-014-0558-0) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13059-014-0558-0
PubMed: 25650807
PubMed Central: 4300615
Affiliations:
- Allemagne, France, Norvège, États-Unis
- Berlin, District de Cologne, Rhénanie-du-Nord-Westphalie, État de New York
- Berlin, Bonn, Cologne
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000D15
- to stream Pmc, to step Curation: 000B76
- to stream Pmc, to step Checkpoint: 000F29
- to stream Ncbi, to step Merge: 002228
- to stream Ncbi, to step Curation: 002228
- to stream Ncbi, to step Checkpoint: 002228
- to stream Main, to step Merge: 002C71
- to stream Main, to step Curation: 002C71
Le document en format XML
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type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO), 69008 Lyons, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO), 69008 Lyons</wicri:regionArea><wicri:noRegion>69008 Lyons</wicri:noRegion><wicri:noRegion>69008 Lyons</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Ruping" sort="Sun, Ruping" uniqKey="Sun R" first="Ruping" last="Sun">Ruping Sun</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff4">Department of Systems Biology, Columbia University, New York, NY 10032 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Systems Biology, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Menon, Roopika" sort="Menon, Roopika" uniqKey="Menon R" first="Roopika" last="Menon">Roopika Menon</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff6">Blackfield AG, Gottfried-Hagen-Str. 60, 51105 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Blackfield AG, Gottfried-Hagen-Str. 60, 51105 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="George, Julie" sort="George, Julie" uniqKey="George J" first="Julie" last="George">Julie George</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Lorenz, Susanne" sort="Lorenz, Susanne" uniqKey="Lorenz S" first="Susanne" last="Lorenz">Susanne Lorenz</name><affiliation wicri:level="1"><nlm:aff id="Aff7">Department of Tumor Biology and Genomics Core Facility, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Tumor Biology and Genomics Core Facility, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea><wicri:noRegion>N-0310 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Meza Zepeda, Leonardo A" sort="Meza Zepeda, Leonardo A" uniqKey="Meza Zepeda L" first="Leonardo A" last="Meza-Zepeda">Leonardo A. Meza-Zepeda</name><affiliation wicri:level="1"><nlm:aff id="Aff7">Department of Tumor Biology and Genomics Core Facility, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Tumor Biology and Genomics Core Facility, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea><wicri:noRegion>N-0310 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Peifer, Martin" sort="Peifer, Martin" uniqKey="Peifer M" first="Martin" last="Peifer">Martin Peifer</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff8">Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Plenker, Dennis" sort="Plenker, Dennis" uniqKey="Plenker D" first="Dennis" last="Plenker">Dennis Plenker</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Heuckmann, Johannes M" sort="Heuckmann, Johannes M" uniqKey="Heuckmann J" first="Johannes M" last="Heuckmann">Johannes M. Heuckmann</name><affiliation wicri:level="3"><nlm:aff id="Aff6">Blackfield AG, Gottfried-Hagen-Str. 60, 51105 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Blackfield AG, Gottfried-Hagen-Str. 60, 51105 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Leenders, Frauke" sort="Leenders, Frauke" uniqKey="Leenders F" first="Frauke" last="Leenders">Frauke Leenders</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Zander, Thomas" sort="Zander, Thomas" uniqKey="Zander T" first="Thomas" last="Zander">Thomas Zander</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff9">Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff10">Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Dahmen, Ilona" sort="Dahmen, Ilona" uniqKey="Dahmen I" first="Ilona" last="Dahmen">Ilona Dahmen</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Koker, Mirjam" sort="Koker, Mirjam" uniqKey="Koker M" first="Mirjam" last="Koker">Mirjam Koker</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Schottle, Jakob" sort="Schottle, Jakob" uniqKey="Schottle J" first="Jakob" last="Schöttle">Jakob Schöttle</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff11">Max Planck Institute for Neurological Research, 50931 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute for Neurological Research, 50931 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Ullrich, Roland T" sort="Ullrich, Roland T" uniqKey="Ullrich R" first="Roland T" last="Ullrich">Roland T. Ullrich</name><affiliation wicri:level="3"><nlm:aff id="Aff8">Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff9">Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff11">Max Planck Institute for Neurological Research, 50931 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute for Neurological Research, 50931 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Altmuller, Janine" sort="Altmuller, Janine" uniqKey="Altmuller J" first="Janine" last="Altmüller">Janine Altmüller</name><affiliation wicri:level="1"><nlm:aff id="Aff12">Cologne Center for Genomics (CCG), University of Cologne, Cologne, 50931 Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne Center for Genomics (CCG), University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff13">Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff14">Institute of Human Genetics, University of Cologne, 50931 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Cologne, 50931 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Becker, Christian" sort="Becker, Christian" uniqKey="Becker C" first="Christian" last="Becker">Christian Becker</name><affiliation wicri:level="1"><nlm:aff id="Aff12">Cologne Center for Genomics (CCG), University of Cologne, Cologne, 50931 Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne Center for Genomics (CCG), University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Nurnberg, Peter" sort="Nurnberg, Peter" uniqKey="Nurnberg P" first="Peter" last="Nürnberg">Peter Nürnberg</name><affiliation wicri:level="1"><nlm:aff id="Aff12">Cologne Center for Genomics (CCG), University of Cologne, Cologne, 50931 Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne Center for Genomics (CCG), University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff13">Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Seidel, Henrik" sort="Seidel, Henrik" uniqKey="Seidel H" first="Henrik" last="Seidel">Henrik Seidel</name><affiliation wicri:level="3"><nlm:aff id="Aff15">Bayer Schering, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bayer Schering, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Bohm, Diana" sort="Bohm, Diana" uniqKey="Bohm D" first="Diana" last="Böhm">Diana Böhm</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Goke, Friederike" sort="Goke, Friederike" uniqKey="Goke F" first="Friederike" last="Göke">Friederike Göke</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Ansen, Sascha" sort="Ansen, Sascha" uniqKey="Ansen S" first="Sascha" last="Ansén">Sascha Ansén</name><affiliation wicri:level="3"><nlm:aff id="Aff9">Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Russell, Prudence A" sort="Russell, Prudence A" uniqKey="Russell P" first="Prudence A" last="Russell">Prudence A. Russell</name><affiliation><nlm:aff id="Aff16">Department of Pathology, St. Vincent’s Hospital, Melbourne, 3065 Victoria Australia</nlm:aff><wicri:noCountry code="subfield">3065 Victoria Australia</wicri:noCountry></affiliation></author><author><name sortKey="Wright, Gavin M" sort="Wright, Gavin M" uniqKey="Wright G" first="Gavin M" last="Wright">Gavin M. Wright</name><affiliation><nlm:aff id="Aff17">University of Melbourne Department of Surgery, St Vincent’s Hospital, Melbourne, 3065 Victoria Australia</nlm:aff><wicri:noCountry code="subfield">3065 Victoria Australia</wicri:noCountry></affiliation></author><author><name sortKey="Wainer, Zoe" sort="Wainer, Zoe" uniqKey="Wainer Z" first="Zoe" last="Wainer">Zoe Wainer</name><affiliation><nlm:aff id="Aff17">University of Melbourne Department of Surgery, St Vincent’s Hospital, Melbourne, 3065 Victoria Australia</nlm:aff><wicri:noCountry code="subfield">3065 Victoria Australia</wicri:noCountry></affiliation></author><author><name sortKey="Solomon, Benjamin" sort="Solomon, Benjamin" uniqKey="Solomon B" first="Benjamin" last="Solomon">Benjamin Solomon</name><affiliation><nlm:aff id="Aff18">Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria Australia</nlm:aff><wicri:noCountry code="subfield">3002 Victoria Australia</wicri:noCountry></affiliation></author><author><name sortKey="Petersen, Iver" sort="Petersen, Iver" uniqKey="Petersen I" first="Iver" last="Petersen">Iver Petersen</name><affiliation wicri:level="1"><nlm:aff id="Aff19">Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Clement, Joachim H" sort="Clement, Joachim H" uniqKey="Clement J" first="Joachim H" last="Clement">Joachim H. Clement</name><affiliation wicri:level="1"><nlm:aff id="Aff20">Department of Internal Medicine II, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine II, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="S Nger, Jorg" sort="S Nger, Jorg" uniqKey="S Nger J" first="Jörg" last="S Nger">Jörg S Nger</name><affiliation wicri:level="1"><nlm:aff id="Aff21">Institute for Pathology Bad Berka, 99438 Bad Berka, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Pathology Bad Berka, 99438 Bad Berka</wicri:regionArea><wicri:noRegion>99438 Bad Berka</wicri:noRegion><wicri:noRegion>99438 Bad Berka</wicri:noRegion><wicri:noRegion>99438 Bad Berka</wicri:noRegion></affiliation></author><author><name sortKey="Brustugun, Odd Terje" sort="Brustugun, Odd Terje" uniqKey="Brustugun O" first="Odd-Terje" last="Brustugun">Odd-Terje Brustugun</name><affiliation wicri:level="1"><nlm:aff id="Aff22">Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo</wicri:regionArea><wicri:noRegion>N-0424 Oslo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff23">Department of Oncology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Oncology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea><wicri:noRegion>N-0310 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Helland, Slaug" sort="Helland, Slaug" uniqKey="Helland " first=" Slaug" last="Helland"> Slaug Helland</name><affiliation wicri:level="1"><nlm:aff id="Aff22">Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo</wicri:regionArea><wicri:noRegion>N-0424 Oslo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff23">Department of Oncology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Oncology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea><wicri:noRegion>N-0310 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Solberg, Steinar" sort="Solberg, Steinar" uniqKey="Solberg S" first="Steinar" last="Solberg">Steinar Solberg</name><affiliation wicri:level="1"><nlm:aff id="Aff24">Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, N-0027 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, N-0027 Oslo</wicri:regionArea><wicri:noRegion>N-0027 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Lund Iversen, Marius" sort="Lund Iversen, Marius" uniqKey="Lund Iversen M" first="Marius" last="Lund-Iversen">Marius Lund-Iversen</name><affiliation wicri:level="1"><nlm:aff id="Aff25">Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea><wicri:noRegion>N-0310 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Buettner, Reinhard" sort="Buettner, Reinhard" uniqKey="Buettner R" first="Reinhard" last="Buettner">Reinhard Buettner</name><affiliation wicri:level="3"><nlm:aff id="Aff10">Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff26">Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Wolf, Jurgen" sort="Wolf, Jurgen" uniqKey="Wolf J" first="Jürgen" last="Wolf">Jürgen Wolf</name><affiliation wicri:level="3"><nlm:aff id="Aff9">Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff10">Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Brambilla, Elisabeth" sort="Brambilla, Elisabeth" uniqKey="Brambilla E" first="Elisabeth" last="Brambilla">Elisabeth Brambilla</name><affiliation wicri:level="1"><nlm:aff id="Aff27">Department of Pathology, CHU Grenoble INSERM U823, Institute Albert Bonniot, 38043 CS10217 Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Pathology, CHU Grenoble INSERM U823, Institute Albert Bonniot, 38043 CS10217 Grenoble</wicri:regionArea><wicri:noRegion>38043 CS10217 Grenoble</wicri:noRegion><wicri:noRegion>38043 CS10217 Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Vingron, Martin" sort="Vingron, Martin" uniqKey="Vingron M" first="Martin" last="Vingron">Martin Vingron</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Perner, Sven" sort="Perner, Sven" uniqKey="Perner S" first="Sven" last="Perner">Sven Perner</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Haas, Stefan A" sort="Haas, Stefan A" uniqKey="Haas S" first="Stefan A" last="Haas">Stefan A. Haas</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Thomas, Roman K" sort="Thomas, Roman K" uniqKey="Thomas R" first="Roman K" last="Thomas">Roman K. Thomas</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff26">Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25650807</idno><idno type="pmc">4300615</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300615</idno><idno type="RBID">PMC:4300615</idno><idno type="doi">10.1186/s13059-014-0558-0</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000D15</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D15</idno><idno type="wicri:Area/Pmc/Curation">000B76</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B76</idno><idno type="wicri:Area/Pmc/Checkpoint">000F29</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F29</idno><idno type="wicri:Area/Ncbi/Merge">002228</idno><idno type="wicri:Area/Ncbi/Curation">002228</idno><idno type="wicri:Area/Ncbi/Checkpoint">002228</idno><idno type="wicri:doubleKey">1465-6906:2015:Fernandez Cuesta L:identification:of:novel</idno><idno type="wicri:Area/Main/Merge">002C71</idno><idno type="wicri:Area/Main/Curation">002C71</idno><idno type="wicri:Area/Main/Exploration">002C71</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data</title><author><name sortKey="Fernandez Cuesta, Lynnette" sort="Fernandez Cuesta, Lynnette" uniqKey="Fernandez Cuesta L" first="Lynnette" last="Fernandez-Cuesta">Lynnette Fernandez-Cuesta</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO), 69008 Lyons, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO), 69008 Lyons</wicri:regionArea><wicri:noRegion>69008 Lyons</wicri:noRegion><wicri:noRegion>69008 Lyons</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Ruping" sort="Sun, Ruping" uniqKey="Sun R" first="Ruping" last="Sun">Ruping Sun</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff4">Department of Systems Biology, Columbia University, New York, NY 10032 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Systems Biology, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Menon, Roopika" sort="Menon, Roopika" uniqKey="Menon R" first="Roopika" last="Menon">Roopika Menon</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff6">Blackfield AG, Gottfried-Hagen-Str. 60, 51105 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Blackfield AG, Gottfried-Hagen-Str. 60, 51105 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="George, Julie" sort="George, Julie" uniqKey="George J" first="Julie" last="George">Julie George</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Lorenz, Susanne" sort="Lorenz, Susanne" uniqKey="Lorenz S" first="Susanne" last="Lorenz">Susanne Lorenz</name><affiliation wicri:level="1"><nlm:aff id="Aff7">Department of Tumor Biology and Genomics Core Facility, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Tumor Biology and Genomics Core Facility, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea><wicri:noRegion>N-0310 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Meza Zepeda, Leonardo A" sort="Meza Zepeda, Leonardo A" uniqKey="Meza Zepeda L" first="Leonardo A" last="Meza-Zepeda">Leonardo A. Meza-Zepeda</name><affiliation wicri:level="1"><nlm:aff id="Aff7">Department of Tumor Biology and Genomics Core Facility, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Tumor Biology and Genomics Core Facility, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea><wicri:noRegion>N-0310 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Peifer, Martin" sort="Peifer, Martin" uniqKey="Peifer M" first="Martin" last="Peifer">Martin Peifer</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff8">Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Plenker, Dennis" sort="Plenker, Dennis" uniqKey="Plenker D" first="Dennis" last="Plenker">Dennis Plenker</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Heuckmann, Johannes M" sort="Heuckmann, Johannes M" uniqKey="Heuckmann J" first="Johannes M" last="Heuckmann">Johannes M. Heuckmann</name><affiliation wicri:level="3"><nlm:aff id="Aff6">Blackfield AG, Gottfried-Hagen-Str. 60, 51105 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Blackfield AG, Gottfried-Hagen-Str. 60, 51105 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Leenders, Frauke" sort="Leenders, Frauke" uniqKey="Leenders F" first="Frauke" last="Leenders">Frauke Leenders</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Zander, Thomas" sort="Zander, Thomas" uniqKey="Zander T" first="Thomas" last="Zander">Thomas Zander</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff9">Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff10">Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Dahmen, Ilona" sort="Dahmen, Ilona" uniqKey="Dahmen I" first="Ilona" last="Dahmen">Ilona Dahmen</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Koker, Mirjam" sort="Koker, Mirjam" uniqKey="Koker M" first="Mirjam" last="Koker">Mirjam Koker</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Schottle, Jakob" sort="Schottle, Jakob" uniqKey="Schottle J" first="Jakob" last="Schöttle">Jakob Schöttle</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff11">Max Planck Institute for Neurological Research, 50931 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute for Neurological Research, 50931 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Ullrich, Roland T" sort="Ullrich, Roland T" uniqKey="Ullrich R" first="Roland T" last="Ullrich">Roland T. Ullrich</name><affiliation wicri:level="3"><nlm:aff id="Aff8">Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff9">Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff11">Max Planck Institute for Neurological Research, 50931 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute for Neurological Research, 50931 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Altmuller, Janine" sort="Altmuller, Janine" uniqKey="Altmuller J" first="Janine" last="Altmüller">Janine Altmüller</name><affiliation wicri:level="1"><nlm:aff id="Aff12">Cologne Center for Genomics (CCG), University of Cologne, Cologne, 50931 Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne Center for Genomics (CCG), University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff13">Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff14">Institute of Human Genetics, University of Cologne, 50931 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Cologne, 50931 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Becker, Christian" sort="Becker, Christian" uniqKey="Becker C" first="Christian" last="Becker">Christian Becker</name><affiliation wicri:level="1"><nlm:aff id="Aff12">Cologne Center for Genomics (CCG), University of Cologne, Cologne, 50931 Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne Center for Genomics (CCG), University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Nurnberg, Peter" sort="Nurnberg, Peter" uniqKey="Nurnberg P" first="Peter" last="Nürnberg">Peter Nürnberg</name><affiliation wicri:level="1"><nlm:aff id="Aff12">Cologne Center for Genomics (CCG), University of Cologne, Cologne, 50931 Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne Center for Genomics (CCG), University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff13">Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Seidel, Henrik" sort="Seidel, Henrik" uniqKey="Seidel H" first="Henrik" last="Seidel">Henrik Seidel</name><affiliation wicri:level="3"><nlm:aff id="Aff15">Bayer Schering, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bayer Schering, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Bohm, Diana" sort="Bohm, Diana" uniqKey="Bohm D" first="Diana" last="Böhm">Diana Böhm</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Goke, Friederike" sort="Goke, Friederike" uniqKey="Goke F" first="Friederike" last="Göke">Friederike Göke</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Ansen, Sascha" sort="Ansen, Sascha" uniqKey="Ansen S" first="Sascha" last="Ansén">Sascha Ansén</name><affiliation wicri:level="3"><nlm:aff id="Aff9">Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Russell, Prudence A" sort="Russell, Prudence A" uniqKey="Russell P" first="Prudence A" last="Russell">Prudence A. Russell</name><affiliation><nlm:aff id="Aff16">Department of Pathology, St. Vincent’s Hospital, Melbourne, 3065 Victoria Australia</nlm:aff><wicri:noCountry code="subfield">3065 Victoria Australia</wicri:noCountry></affiliation></author><author><name sortKey="Wright, Gavin M" sort="Wright, Gavin M" uniqKey="Wright G" first="Gavin M" last="Wright">Gavin M. Wright</name><affiliation><nlm:aff id="Aff17">University of Melbourne Department of Surgery, St Vincent’s Hospital, Melbourne, 3065 Victoria Australia</nlm:aff><wicri:noCountry code="subfield">3065 Victoria Australia</wicri:noCountry></affiliation></author><author><name sortKey="Wainer, Zoe" sort="Wainer, Zoe" uniqKey="Wainer Z" first="Zoe" last="Wainer">Zoe Wainer</name><affiliation><nlm:aff id="Aff17">University of Melbourne Department of Surgery, St Vincent’s Hospital, Melbourne, 3065 Victoria Australia</nlm:aff><wicri:noCountry code="subfield">3065 Victoria Australia</wicri:noCountry></affiliation></author><author><name sortKey="Solomon, Benjamin" sort="Solomon, Benjamin" uniqKey="Solomon B" first="Benjamin" last="Solomon">Benjamin Solomon</name><affiliation><nlm:aff id="Aff18">Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria Australia</nlm:aff><wicri:noCountry code="subfield">3002 Victoria Australia</wicri:noCountry></affiliation></author><author><name sortKey="Petersen, Iver" sort="Petersen, Iver" uniqKey="Petersen I" first="Iver" last="Petersen">Iver Petersen</name><affiliation wicri:level="1"><nlm:aff id="Aff19">Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Clement, Joachim H" sort="Clement, Joachim H" uniqKey="Clement J" first="Joachim H" last="Clement">Joachim H. Clement</name><affiliation wicri:level="1"><nlm:aff id="Aff20">Department of Internal Medicine II, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine II, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="S Nger, Jorg" sort="S Nger, Jorg" uniqKey="S Nger J" first="Jörg" last="S Nger">Jörg S Nger</name><affiliation wicri:level="1"><nlm:aff id="Aff21">Institute for Pathology Bad Berka, 99438 Bad Berka, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Pathology Bad Berka, 99438 Bad Berka</wicri:regionArea><wicri:noRegion>99438 Bad Berka</wicri:noRegion><wicri:noRegion>99438 Bad Berka</wicri:noRegion><wicri:noRegion>99438 Bad Berka</wicri:noRegion></affiliation></author><author><name sortKey="Brustugun, Odd Terje" sort="Brustugun, Odd Terje" uniqKey="Brustugun O" first="Odd-Terje" last="Brustugun">Odd-Terje Brustugun</name><affiliation wicri:level="1"><nlm:aff id="Aff22">Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo</wicri:regionArea><wicri:noRegion>N-0424 Oslo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff23">Department of Oncology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Oncology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea><wicri:noRegion>N-0310 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Helland, Slaug" sort="Helland, Slaug" uniqKey="Helland " first=" Slaug" last="Helland"> Slaug Helland</name><affiliation wicri:level="1"><nlm:aff id="Aff22">Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0424 Oslo</wicri:regionArea><wicri:noRegion>N-0424 Oslo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff23">Department of Oncology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Oncology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea><wicri:noRegion>N-0310 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Solberg, Steinar" sort="Solberg, Steinar" uniqKey="Solberg S" first="Steinar" last="Solberg">Steinar Solberg</name><affiliation wicri:level="1"><nlm:aff id="Aff24">Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, N-0027 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, N-0027 Oslo</wicri:regionArea><wicri:noRegion>N-0027 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Lund Iversen, Marius" sort="Lund Iversen, Marius" uniqKey="Lund Iversen M" first="Marius" last="Lund-Iversen">Marius Lund-Iversen</name><affiliation wicri:level="1"><nlm:aff id="Aff25">Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea><wicri:noRegion>N-0310 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Buettner, Reinhard" sort="Buettner, Reinhard" uniqKey="Buettner R" first="Reinhard" last="Buettner">Reinhard Buettner</name><affiliation wicri:level="3"><nlm:aff id="Aff10">Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff26">Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Wolf, Jurgen" sort="Wolf, Jurgen" uniqKey="Wolf J" first="Jürgen" last="Wolf">Jürgen Wolf</name><affiliation wicri:level="3"><nlm:aff id="Aff9">Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff10">Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Brambilla, Elisabeth" sort="Brambilla, Elisabeth" uniqKey="Brambilla E" first="Elisabeth" last="Brambilla">Elisabeth Brambilla</name><affiliation wicri:level="1"><nlm:aff id="Aff27">Department of Pathology, CHU Grenoble INSERM U823, Institute Albert Bonniot, 38043 CS10217 Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Pathology, CHU Grenoble INSERM U823, Institute Albert Bonniot, 38043 CS10217 Grenoble</wicri:regionArea><wicri:noRegion>38043 CS10217 Grenoble</wicri:noRegion><wicri:noRegion>38043 CS10217 Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Vingron, Martin" sort="Vingron, Martin" uniqKey="Vingron M" first="Martin" last="Vingron">Martin Vingron</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Perner, Sven" sort="Perner, Sven" uniqKey="Perner S" first="Sven" last="Perner">Sven Perner</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Haas, Stefan A" sort="Haas, Stefan A" uniqKey="Haas S" first="Stefan A" last="Haas">Stefan A. Haas</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, D-14195 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Thomas, Roman K" sort="Thomas, Roman K" uniqKey="Thomas R" first="Roman K" last="Thomas">Roman K. Thomas</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50924 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff26">Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Hospital Medical Center, University of Cologne, 50937 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author></analytic><series><title level="j">Genome Biology</title><idno type="ISSN">1465-6906</idno><idno type="eISSN">1465-6914</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Genomic translocation events frequently underlie cancer development through generation of gene fusions with oncogenic properties. Identification of such fusion transcripts by transcriptome sequencing might help to discover new potential therapeutic targets. We developed TRUP (Tumor-specimen suited RNA-seq Unified Pipeline) (<ext-link ext-link-type="uri" xlink:href="https://github.com/ruping/TRUP">https://github.com/ruping/TRUP</ext-link>), a computational approach that combines split-read and read-pair analysis with <italic>de novo</italic> assembly for the identification of chimeric transcripts in cancer specimens. We apply TRUP to RNA-seq data of different tumor types, and find it to be more sensitive than alternative tools in detecting chimeric transcripts, such as secondary rearrangements in <italic>EML4-ALK</italic>-positive lung tumors, or recurrent inactivating rearrangements affecting <italic>RASSF8</italic>.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s13059-014-0558-0) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Weinstein, Ib" uniqKey="Weinstein I">IB Weinstein</name></author><author><name sortKey="Joe, A" uniqKey="Joe A">A Joe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ben Neriah, Y" uniqKey="Ben Neriah Y">Y Ben-Neriah</name></author><author><name sortKey="Daley, Gq" uniqKey="Daley G">GQ Daley</name></author><author><name sortKey="Mes Masson, A M" uniqKey="Mes Masson A">A-M Mes-Masson</name></author><author><name sortKey="Witte, On" uniqKey="Witte O">ON Witte</name></author><author><name sortKey="Baltimore, D" uniqKey="Baltimore D">D Baltimore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kwak, El" uniqKey="Kwak E">EL Kwak</name></author><author><name sortKey="Bang, Y J" uniqKey="Bang Y">Y-J Bang</name></author><author><name sortKey="Camidge, Dr" uniqKey="Camidge D">DR Camidge</name></author><author><name sortKey="Shaw, At" uniqKey="Shaw A">AT Shaw</name></author><author><name sortKey="Solomon, B" uniqKey="Solomon B">B Solomon</name></author><author><name sortKey="Maki, Rg" uniqKey="Maki R">RG Maki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maher, Ca" uniqKey="Maher C">CA Maher</name></author><author><name sortKey="Palanisamy, N" uniqKey="Palanisamy N">N Palanisamy</name></author><author><name sortKey="Brenner, Jc" uniqKey="Brenner J">JC Brenner</name></author><author><name sortKey="Cao, X" uniqKey="Cao X">X Cao</name></author><author><name sortKey="Kalyana Sundaram, S" uniqKey="Kalyana Sundaram S">S Kalyana-Sundaram</name></author><author><name sortKey="Luo, S" uniqKey="Luo S">S Luo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Xia, J" uniqKey="Xia J">J Xia</name></author><author><name sortKey="Jia, P" uniqKey="Jia P">P Jia</name></author><author><name sortKey="Pao, W" uniqKey="Pao W">W Pao</name></author><author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sboner, A" uniqKey="Sboner A">A Sboner</name></author><author><name sortKey="Habegger, L" uniqKey="Habegger L">L Habegger</name></author><author><name sortKey="Pflueger, D" uniqKey="Pflueger D">D Pflueger</name></author><author><name sortKey="Terry, S" uniqKey="Terry S">S 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uniqKey="Zerbino D">DR Zerbino</name></author><author><name sortKey="Vingron, M" uniqKey="Vingron M">M Vingron</name></author><author><name sortKey="Birney, E" uniqKey="Birney E">E Birney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sasaki, T" uniqKey="Sasaki T">T Sasaki</name></author><author><name sortKey="Rodig, Sj" uniqKey="Rodig S">SJ Rodig</name></author><author><name sortKey="Chirieac, Lr" uniqKey="Chirieac L">LR Chirieac</name></author><author><name sortKey="J Nne, Pa" uniqKey="J Nne P">PA Jänne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rudin, Cm" uniqKey="Rudin C">CM Rudin</name></author><author><name sortKey="Durinck, S" uniqKey="Durinck S">S Durinck</name></author><author><name sortKey="Stawiski, Ew" uniqKey="Stawiski E">EW Stawiski</name></author><author><name sortKey="Poirier, Jt" uniqKey="Poirier J">JT Poirier</name></author><author><name sortKey="Modrusan, Z" uniqKey="Modrusan Z">Z Modrusan</name></author><author><name sortKey="Shames, Ds" uniqKey="Shames D">DS Shames</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pasqualucci, L" uniqKey="Pasqualucci L">L Pasqualucci</name></author><author><name sortKey="Dominguez Sola, D" uniqKey="Dominguez Sola D">D Dominguez-Sola</name></author><author><name sortKey="Chiarenza, A" uniqKey="Chiarenza A">A Chiarenza</name></author><author><name sortKey="Fabbri, G" uniqKey="Fabbri G">G Fabbri</name></author><author><name sortKey="Grunn, A" uniqKey="Grunn A">A Grunn</name></author><author><name sortKey="Trifonov, V" uniqKey="Trifonov V">V Trifonov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peifer, M" uniqKey="Peifer M">M Peifer</name></author><author><name sortKey="Fernandez Cuesta, L" uniqKey="Fernandez Cuesta L">L Fernández-Cuesta</name></author><author><name sortKey="Sos, Ml" uniqKey="Sos M">ML Sos</name></author><author><name sortKey="George, J" uniqKey="George J">J George</name></author><author><name sortKey="Seidel, D" uniqKey="Seidel D">D Seidel</name></author><author><name sortKey="Kasper, Lh" uniqKey="Kasper L">LH Kasper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Mor, G" uniqKey="Mor G">G Mor</name></author><author><name sortKey="Sklar, J" uniqKey="Sklar J">J Sklar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Chien, J" uniqKey="Chien J">J Chien</name></author><author><name sortKey="Smith, Di" uniqKey="Smith D">DI Smith</name></author><author><name sortKey="Ma, J" uniqKey="Ma J">J Ma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jia, W" uniqKey="Jia W">W Jia</name></author><author><name sortKey="Qiu, K" uniqKey="Qiu K">K Qiu</name></author><author><name sortKey="He, M" uniqKey="He M">M He</name></author><author><name sortKey="Song, P" uniqKey="Song P">P Song</name></author><author><name sortKey="Zhou, Q" uniqKey="Zhou Q">Q Zhou</name></author><author><name sortKey="Zhou, F" uniqKey="Zhou F">F Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sherwood, V" uniqKey="Sherwood V">V Sherwood</name></author><author><name sortKey="Recino, A" uniqKey="Recino A">A Recino</name></author><author><name sortKey="Jeffries, A" uniqKey="Jeffries A">A Jeffries</name></author><author><name sortKey="Ward, A" uniqKey="Ward A">A Ward</name></author><author><name sortKey="Chalmers, Ad" uniqKey="Chalmers A">AD Chalmers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falvella, Fs" uniqKey="Falvella F">FS Falvella</name></author><author><name sortKey="Manenti, G" uniqKey="Manenti G">G Manenti</name></author><author><name sortKey="Spinola, M" uniqKey="Spinola M">M Spinola</name></author><author><name sortKey="Pignatiello, C" uniqKey="Pignatiello C">C Pignatiello</name></author><author><name sortKey="Conti, B" uniqKey="Conti B">B Conti</name></author><author><name sortKey="Pastorino, U" uniqKey="Pastorino U">U Pastorino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lock, Fe" uniqKey="Lock F">FE Lock</name></author><author><name sortKey="Underhill Day, N" uniqKey="Underhill Day N">N Underhill-Day</name></author><author><name sortKey="Dunwell, T" uniqKey="Dunwell T">T Dunwell</name></author><author><name sortKey="Matallanas, D" uniqKey="Matallanas D">D Matallanas</name></author><author><name sortKey="Cooper, W" uniqKey="Cooper W">W Cooper</name></author><author><name sortKey="Hesson, L" uniqKey="Hesson L">L Hesson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grant, Gr" uniqKey="Grant G">GR Grant</name></author><author><name sortKey="Farkas, Mh" uniqKey="Farkas M">MH Farkas</name></author><author><name sortKey="Pizarro, Ad" uniqKey="Pizarro A">AD Pizarro</name></author><author><name sortKey="Lahens, Nf" uniqKey="Lahens N">NF Lahens</name></author><author><name sortKey="Schug, J" uniqKey="Schug J">J Schug</name></author><author><name sortKey="Brunk, Bp" uniqKey="Brunk B">BP Brunk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garber, M" uniqKey="Garber M">M Garber</name></author><author><name sortKey="Grabherr, Mg" uniqKey="Grabherr M">MG Grabherr</name></author><author><name sortKey="Guttman, M" uniqKey="Guttman M">M Guttman</name></author><author><name sortKey="Trapnell, C" uniqKey="Trapnell C">C Trapnell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kent, Wj" uniqKey="Kent W">WJ Kent</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Scheble, Vj" uniqKey="Scheble V">VJ Scheble</name></author><author><name sortKey="Braun, M" uniqKey="Braun M">M Braun</name></author><author><name sortKey="Beroukhim, R" uniqKey="Beroukhim R">R Beroukhim</name></author><author><name sortKey="Mermel, Ch" uniqKey="Mermel C">CH Mermel</name></author><author><name sortKey="Ruiz, C" uniqKey="Ruiz C">C Ruiz</name></author><author><name sortKey="Wilbertz, T" uniqKey="Wilbertz T">T Wilbertz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>France</li><li>Norvège</li><li>États-Unis</li></country><region><li>Berlin</li><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li><li>État de New York</li></region><settlement><li>Berlin</li><li>Bonn</li><li>Cologne</li></settlement></list><tree><noCountry><name sortKey="Russell, Prudence A" sort="Russell, Prudence A" uniqKey="Russell P" first="Prudence A" last="Russell">Prudence A. Russell</name><name sortKey="Solomon, Benjamin" sort="Solomon, Benjamin" uniqKey="Solomon B" first="Benjamin" last="Solomon">Benjamin Solomon</name><name sortKey="Wainer, Zoe" sort="Wainer, Zoe" uniqKey="Wainer Z" first="Zoe" last="Wainer">Zoe Wainer</name><name sortKey="Wright, Gavin M" sort="Wright, Gavin M" uniqKey="Wright G" first="Gavin M" last="Wright">Gavin M. Wright</name></noCountry><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Fernandez Cuesta, Lynnette" sort="Fernandez Cuesta, Lynnette" uniqKey="Fernandez Cuesta L" first="Lynnette" last="Fernandez-Cuesta">Lynnette Fernandez-Cuesta</name></region><name sortKey="Altmuller, Janine" sort="Altmuller, Janine" uniqKey="Altmuller J" first="Janine" last="Altmüller">Janine Altmüller</name><name sortKey="Altmuller, Janine" sort="Altmuller, Janine" uniqKey="Altmuller J" first="Janine" last="Altmüller">Janine Altmüller</name><name sortKey="Altmuller, Janine" sort="Altmuller, Janine" uniqKey="Altmuller J" first="Janine" last="Altmüller">Janine Altmüller</name><name sortKey="Ansen, Sascha" sort="Ansen, Sascha" uniqKey="Ansen S" first="Sascha" last="Ansén">Sascha Ansén</name><name sortKey="Becker, Christian" sort="Becker, Christian" uniqKey="Becker C" first="Christian" last="Becker">Christian Becker</name><name sortKey="Bohm, Diana" sort="Bohm, Diana" uniqKey="Bohm D" first="Diana" last="Böhm">Diana Böhm</name><name sortKey="Buettner, Reinhard" sort="Buettner, Reinhard" uniqKey="Buettner R" first="Reinhard" last="Buettner">Reinhard Buettner</name><name sortKey="Buettner, Reinhard" sort="Buettner, Reinhard" uniqKey="Buettner R" first="Reinhard" last="Buettner">Reinhard Buettner</name><name sortKey="Clement, Joachim H" sort="Clement, Joachim H" uniqKey="Clement J" first="Joachim H" last="Clement">Joachim H. Clement</name><name sortKey="Dahmen, Ilona" sort="Dahmen, Ilona" uniqKey="Dahmen I" first="Ilona" last="Dahmen">Ilona Dahmen</name><name sortKey="George, Julie" sort="George, Julie" uniqKey="George J" first="Julie" last="George">Julie George</name><name sortKey="Goke, Friederike" sort="Goke, Friederike" uniqKey="Goke F" first="Friederike" last="Göke">Friederike Göke</name><name sortKey="Haas, Stefan A" sort="Haas, Stefan A" uniqKey="Haas S" first="Stefan A" last="Haas">Stefan A. Haas</name><name sortKey="Heuckmann, Johannes M" sort="Heuckmann, Johannes M" uniqKey="Heuckmann J" first="Johannes M" last="Heuckmann">Johannes M. Heuckmann</name><name sortKey="Koker, Mirjam" sort="Koker, Mirjam" uniqKey="Koker M" first="Mirjam" last="Koker">Mirjam Koker</name><name sortKey="Leenders, Frauke" sort="Leenders, Frauke" uniqKey="Leenders F" first="Frauke" last="Leenders">Frauke Leenders</name><name sortKey="Menon, Roopika" sort="Menon, Roopika" uniqKey="Menon R" first="Roopika" last="Menon">Roopika Menon</name><name sortKey="Menon, Roopika" sort="Menon, Roopika" uniqKey="Menon R" first="Roopika" last="Menon">Roopika Menon</name><name sortKey="Nurnberg, Peter" sort="Nurnberg, Peter" uniqKey="Nurnberg P" first="Peter" last="Nürnberg">Peter Nürnberg</name><name sortKey="Nurnberg, Peter" sort="Nurnberg, Peter" uniqKey="Nurnberg P" first="Peter" last="Nürnberg">Peter Nürnberg</name><name sortKey="Peifer, Martin" sort="Peifer, Martin" uniqKey="Peifer M" first="Martin" last="Peifer">Martin Peifer</name><name sortKey="Peifer, Martin" sort="Peifer, Martin" uniqKey="Peifer M" first="Martin" last="Peifer">Martin Peifer</name><name sortKey="Perner, Sven" sort="Perner, Sven" uniqKey="Perner S" first="Sven" last="Perner">Sven Perner</name><name sortKey="Petersen, Iver" sort="Petersen, Iver" uniqKey="Petersen I" first="Iver" last="Petersen">Iver Petersen</name><name sortKey="Plenker, Dennis" sort="Plenker, Dennis" uniqKey="Plenker D" first="Dennis" last="Plenker">Dennis Plenker</name><name sortKey="S Nger, Jorg" sort="S Nger, Jorg" uniqKey="S Nger J" first="Jörg" last="S Nger">Jörg S Nger</name><name sortKey="Schottle, Jakob" sort="Schottle, Jakob" uniqKey="Schottle J" first="Jakob" last="Schöttle">Jakob Schöttle</name><name sortKey="Schottle, Jakob" sort="Schottle, Jakob" uniqKey="Schottle J" first="Jakob" last="Schöttle">Jakob Schöttle</name><name sortKey="Seidel, Henrik" sort="Seidel, Henrik" uniqKey="Seidel H" first="Henrik" last="Seidel">Henrik Seidel</name><name sortKey="Sun, Ruping" sort="Sun, Ruping" uniqKey="Sun R" first="Ruping" last="Sun">Ruping Sun</name><name sortKey="Thomas, Roman K" sort="Thomas, Roman K" uniqKey="Thomas R" first="Roman K" last="Thomas">Roman K. Thomas</name><name sortKey="Thomas, Roman K" sort="Thomas, Roman K" uniqKey="Thomas R" first="Roman K" last="Thomas">Roman K. Thomas</name><name sortKey="Ullrich, Roland T" sort="Ullrich, Roland T" uniqKey="Ullrich R" first="Roland T" last="Ullrich">Roland T. Ullrich</name><name sortKey="Ullrich, Roland T" sort="Ullrich, Roland T" uniqKey="Ullrich R" first="Roland T" last="Ullrich">Roland T. Ullrich</name><name sortKey="Ullrich, Roland T" sort="Ullrich, Roland T" uniqKey="Ullrich R" first="Roland T" last="Ullrich">Roland T. Ullrich</name><name sortKey="Vingron, Martin" sort="Vingron, Martin" uniqKey="Vingron M" first="Martin" last="Vingron">Martin Vingron</name><name sortKey="Wolf, Jurgen" sort="Wolf, Jurgen" uniqKey="Wolf J" first="Jürgen" last="Wolf">Jürgen Wolf</name><name sortKey="Wolf, Jurgen" sort="Wolf, Jurgen" uniqKey="Wolf J" first="Jürgen" last="Wolf">Jürgen Wolf</name><name sortKey="Zander, Thomas" sort="Zander, Thomas" uniqKey="Zander T" first="Thomas" last="Zander">Thomas Zander</name><name sortKey="Zander, Thomas" sort="Zander, Thomas" uniqKey="Zander T" first="Thomas" last="Zander">Thomas Zander</name><name sortKey="Zander, Thomas" sort="Zander, Thomas" uniqKey="Zander T" first="Thomas" last="Zander">Thomas Zander</name></country><country name="France"><noRegion><name sortKey="Fernandez Cuesta, Lynnette" sort="Fernandez Cuesta, Lynnette" uniqKey="Fernandez Cuesta L" first="Lynnette" last="Fernandez-Cuesta">Lynnette Fernandez-Cuesta</name></noRegion><name sortKey="Brambilla, Elisabeth" sort="Brambilla, Elisabeth" uniqKey="Brambilla E" first="Elisabeth" last="Brambilla">Elisabeth Brambilla</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Sun, Ruping" sort="Sun, Ruping" uniqKey="Sun R" first="Ruping" last="Sun">Ruping Sun</name></region></country><country name="Norvège"><noRegion><name sortKey="Lorenz, Susanne" sort="Lorenz, Susanne" uniqKey="Lorenz S" first="Susanne" last="Lorenz">Susanne Lorenz</name></noRegion><name sortKey="Brustugun, Odd Terje" sort="Brustugun, Odd Terje" uniqKey="Brustugun O" first="Odd-Terje" last="Brustugun">Odd-Terje Brustugun</name><name sortKey="Brustugun, Odd Terje" sort="Brustugun, Odd Terje" uniqKey="Brustugun O" first="Odd-Terje" last="Brustugun">Odd-Terje Brustugun</name><name sortKey="Helland, Slaug" sort="Helland, Slaug" uniqKey="Helland " first=" Slaug" last="Helland"> Slaug Helland</name><name sortKey="Helland, Slaug" sort="Helland, Slaug" uniqKey="Helland " first=" Slaug" last="Helland"> Slaug Helland</name><name sortKey="Lund Iversen, Marius" sort="Lund Iversen, Marius" uniqKey="Lund Iversen M" first="Marius" last="Lund-Iversen">Marius Lund-Iversen</name><name sortKey="Meza Zepeda, Leonardo A" sort="Meza Zepeda, Leonardo A" uniqKey="Meza Zepeda L" first="Leonardo A" last="Meza-Zepeda">Leonardo A. Meza-Zepeda</name><name sortKey="Solberg, Steinar" sort="Solberg, Steinar" uniqKey="Solberg S" first="Steinar" last="Solberg">Steinar Solberg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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